Feb 4, - The condition causes heartburn and can damage the esophagus. Aciphex may be used to treat GERD in children between 1 and 11 years. Jan 17, - Aciphex. Aciphex (rabeprazole sodium) is a proton pump inhibitor (PPI) to reduce stomach acid and is used for the treatment of gastroesophageal reflux disease (GERD), duodenal ulcers, and used in combination with antibiotics to treat Helicobacter pylori (H. pylori) bacterial infections in the stomach. Information about the drug rabeprazole (Aciphex), a PPI prescribed for treating Rabeprazole can be taken with or without meals since food has little effect on its absorption. Use in pregnant women has not been adequately evaluated.